Letter | Published:

Evidence of Side-Chain Cleavage during the Reaction of Epinephrine and Norepinephrine with Ethylene Diamine


IN a previous communication1, we reported that several products are obtained from the condensation of epinephrine and norepinephrine with ethylene diamine according to the Weil-Malherbe and Bone procedure2. Recently Yagi and Nagatsu3 have suggested that the main product from norepinephrine in this reaction is identical with a secondary product of epinephrine probably by a process of demethylation of the latter.

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  1. 1

    Nadeau, G., and Joly, L. P., Nature, 182, 180 (1958).

  2. 2

    Weil-Malherbe, H., and Bone, A. D., Biochem. J., 51, 311 (1952).

  3. 3

    Yagi, K., and Nagatsu, T., Nature, 183, 822 (1959).

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