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Distribution in the Mouse of Lethal and Sub-lethal Doses of Cottonmouth Moccasin Venom labelled with Iodine-131

Abstract

THOUGH disease and death from the bite of the poisonous snake is considered not unusual, and treatment has become more or less standardized, little is actually known about the site of action of snake venom in vivo. The value of a radioactive tag for studies of this sort is evident, and therefore, an attempt was made to label the whole dried venom of the cottonmouth moccasin(Ancistrodon p. piscivorus) with iodine-131, evaluate its toxicity relative to the original venom preparation, and chart its distribution in the mouse after injection of lethal or sublethal doses.

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GENNARO, J., RAMSEY, H. Distribution in the Mouse of Lethal and Sub-lethal Doses of Cottonmouth Moccasin Venom labelled with Iodine-131. Nature 184, 1244–1245 (1959). https://doi.org/10.1038/1841244b0

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  • DOI: https://doi.org/10.1038/1841244b0

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