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Prevention of Foetal Development by Enzyme Inhibition

Nature volume 184, pages 1238–1239 (1959)Cite this article

Abstract

IT has been shown recently that fœtuses of rats and humans at a definite phase of development produce histamine at a very high rate.1–3. Towards the end of pregnancy an average sized set of rat fœtuses produces about ten times more histamine than the mother in a given time and about fifty times more per unit weight. The fœtal histamine enters the mother's circulation and is then in part destroyed, in part excreted in the urine. Fœtal tissues bind histamine only loosely, they thus contain little, and produce it at a high rate3. As a working hypothesis it would seem that the striking histamine-forming capacity of the fœtus might be related to growth in general. To test this hypothesis we have investigated histamine formation in the regenerating liver.

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References

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Authors and Affiliations

  1. Institute of Physiology, University of Lund, Sweden

    G. KAHLSON & ELSA ROSENGREN

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  1. G. KAHLSON
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  2. ELSA ROSENGREN
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KAHLSON, G., ROSENGREN, E. Prevention of Foetal Development by Enzyme Inhibition. Nature 184, 1238–1239 (1959). https://doi.org/10.1038/1841238a0

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