Abstract
HALPERN1 has shown that the injection of dextran into albino rats causes increased capillary permeability and shock. Coincident with the appearance of shock, there is a massive release of histamine into the blood stream of injected animals. The liberated histamine probably accounts for the greater part of the increased capillary permeability and shock resulting from the administration of dextran. It seemed of interest, therefore, to investigate the mechanism of the release of histamine. It was found that dextran reacts with a plasma protein to produce a substance which acts on mast cells to release histamine.
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References
Halpern, B. N., Ciba Foundation Symposium on Histamine, 92 (Churchill, London, 1956).
Archer, G. T., Aust. J. Exp. Biol. and Mech. Sci. (in the press).
Lowry, O. H., Graham, Helen T., Harris, Frances B., Priebat, Martha K., Marks, A. R., and Bregman, R. U., J. Pharmacol and Exp. Therap., 112, 116 (1954).
Archer, G. T., Nature, 182, 726 (1958).
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ARCHER, G. Release of Histamine from Rat Mast Cells by Blood Treated with Dextran. Nature 184, 1151–1152 (1959). https://doi.org/10.1038/1841151c0
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DOI: https://doi.org/10.1038/1841151c0
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