Abstract
THE role of a coenzyme is studied mostly with respect to the mechanism of reactions catalysed by specific enzymes. It has been established in some cases that coenzymes and prosthetic groups have a protecting and stabilizing effect on the protein molecule. It is known that the large molecule of D-glyceralde-hyde-3-phosphate dehydrogenase (PGAD) (molecular weight 140,000) is labile, and does not contain disulphide linkages as stabilizing bonds1.
References
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Szabolcsi, G., Acta Physiol. Hung., 13, 214 (1958).
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ELŐDI, P., SZABOLCSI, G. Role of the Coenzyme in the Stabilization of Glyceraldehyde-3-phosphate Dehydrogenase. Nature 184, 56 (1959). https://doi.org/10.1038/184056a0
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DOI: https://doi.org/10.1038/184056a0
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