THE role of a coenzyme is studied mostly with respect to the mechanism of reactions catalysed by specific enzymes. It has been established in some cases that coenzymes and prosthetic groups have a protecting and stabilizing effect on the protein molecule. It is known that the large molecule of D-glyceralde-hyde-3-phosphate dehydrogenase (PGAD) (molecular weight 140,000) is labile, and does not contain disulphide linkages as stabilizing bonds1.
Velick, S. F., in McElroy, W. D., and Glass, B., ed., “The Mechanism of Enzyme Action” 491 (Johns Hopkins Press, Baltimore 1954).
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Elődi, P., and Szörényi, E., Acta Physiol. Hung., 9, 339 (1956).
Szabolcsi, G., Acta Physiol. Hung., 13, 214 (1958).
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ELŐDI, P., SZABOLCSI, G. Role of the Coenzyme in the Stabilization of Glyceraldehyde-3-phosphate Dehydrogenase. Nature 184, 56 (1959). https://doi.org/10.1038/184056a0
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