Abstract
THE presence of a thromboplastin-generating system in blood has been shown by Biggs, Douglas and Macfarlane1. It is now recognized that at least six different factors participate in the formation of ‘blood thromboplastin’ and that a series of reactions resulting in the production of hypothetical intermediates such as product I and product II (Table 1) precede the appearance of the active prothrombin-converting substance2,3.
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References
Biggs, R., Douglas, A. S., and Macfarlane, R. G., J. Physiol., 119, 89 (1953).
Bergsagel, D. E., and Hougie, C., Brit. J. Haemat., 2, 113 (1956).
Hougie, Cecil, J. Lab. Clin. Med., 50, 61 (1957).
Lewis, M. L., and Ware, A. G., Proc. Soc. Exp. Biol. and Med., 84, 636 (1953).
Rhodes, Marvin B., Hill, Robert M., and Feeney, Robert E., Anal. Chem., 29, 376 (1957).
Johnston, Betty R., and Jensen, H., Amer. J. Physiol., 194, 1 (1958).
Arscott, Phyllis M., Koppel, J. L., and Olwin, John H., J. Lab. Clin. Med., 52, 962 (1958).
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ARSCOTT, P., KOPPEL, J. & OLWIN, J. Arginine Esterase Activity of ‘Blood Thromboplastin’. Nature 183, 753–754 (1959). https://doi.org/10.1038/183753a0
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DOI: https://doi.org/10.1038/183753a0
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