Abstract
THE stability constants of a series of ligands of the type, NH2.CH2.CO.X, with the ions Cu(II), Co(II) and Mn(II), have been measured in this laboratory1, and it has been shown that, for any one of the metals, a linear relationship exists between log K
1 (first stability constant) and pK
a (acid dissociation constant of the amino-group)2. The group X can have a variety of structures ranging from O− (glycine) to NH2 and NH.CH2.COO− (glycinamide and glycylglycine). From these observations it was concluded that the structure of the metal complexes was best represented thus: 
For Cu(II) this structure only applies to the complexes initially formed, prior to the onset of additional acid dissociations which occur for some of the ligands.
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References
Datta, S. P., and Rabin, B. R., Trans. Farad. Soc., 52, 1117 and 1123 (1956).
Datta, S. P., and Rabin, B. R., Biochim. Biophys. Acta, 19, 572 (1956). Rabin, B. R., Trans. Farad. Soc., 52, 1131 (1956); Biochem. Soc. Symposia, 15, 21 (1958).
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Jones, J. G., Poole, J. B., Tomkinson, J. C., and Williams, R. J. P., J. Chem. Soc., 2001 (1958).
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DATTA, S., LEBERMAN, R. & RABIN, B. Relationship between Proton and Metal Binding by some Peptides, Amino-acid Amides and Amino-acids. Nature 183, 745–746 (1959). https://doi.org/10.1038/183745a0
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DOI: https://doi.org/10.1038/183745a0
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