Abstract
THE fact that cortisone has an inhibitory effect on growth of chicken embryos was first noted in 19471. A detailed study of this phenomenon was afterwards undertaken by Karnofsky, Ridgway and Patterson2 and their observations were confirmed by Yamada3 and by Siegel, Smith and Gerstl4. Cavallero, di Marco, Fuoco and Sala5 secured evidence indicating that the growth-inhibiting effect of cortisone is brought about by an interference with protein synthesis, and an excess of hydroxyproline found by Roberts, Karnofsky and Frankel6 after cortisone treatment presumably points to the same conclusion. In experiments with weanling rats, Tuchmann-Duplessis and Mercier-Parot7 failed to counteract the growth-inhibitory action of cortisone by concurrent treatment with somatotropic pituitary hormone, glucosamine or the polysaccharide fraction of human placenta. In chicken embryos, on the other hand, Sobel8 observed that the deleterious effects of cortisone on growth and survival were partially counteracted by simultaneous administration of somatotropic pituitary hormone.
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References
Landauer, W., Endocrinol., 41, 489 (1947).
Karnofsky, D. A., Ridgway, L. P., and Patterson, P. A., Endocrinol., 48, 596 (1951).
Yamada, Y., Agric. Bull. Saga Univ., No. 2, 35 (1954).
Siegel, B. V., Smith, M. J., and Gerstl, B., Arch. Pathol., 63, 562 (1957).
Cavallero, C., di Marco, A., Fuoco, L., and Sala, G., Proc. Soc. Exp. Biol. Med., 81, 619 (1952).
Roberts, E., Karnofsky, D. A., and Frankel, S., Proc. Soc. Exp. Biol. Med., 76, 289 (1951).
Tuchmann-Duplessis, H., and Mercier-Parot, L., Etudes Néonatales, 7, 101 (1958).
Sobel, H., Proc. Soc. Exp. Biol. Med., 97, 495 (1958).
Montgomery, P. O'B., Proc. Soc. Exp. Biol. Med., 90, 410 (1955).
De Franciscis, P., and Magri, E., Boll. Soc. Ital. Biol. Sper., 33, 1623 (1957).
De Franciscis, P., Magri, E., and Verdoliva, A., Rassegna Med. Sper. (in the press).
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DE FRANCISCIS, P., LANDAUER, W. Effect of Amniotic Fluid on Inhibition of Growth by Cortisone in Chicken Embryos. Nature 183, 617–618 (1959). https://doi.org/10.1038/183617a0
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DOI: https://doi.org/10.1038/183617a0
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