Abstract
5-MERCAPTOURACIL, a structural analogue of thymine, was synthesized several years ago1,2. This compound (and its disulphide) inhibited the growth of Lactobacillus leichmannii at 1–3 µgm./ml. concentration, and this inhibition could be reversed ‘competitively’ with thymine. It was tested in several experimental mouse tumours; in some cases, it caused tumour inhibition of borderline significance, at less than the maximum tolerated dose3.
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BARDOS, T., SEGALOFF, A. & AMBRUS, J. Anti-Tumour Activity of 5-Mercaptouracil. Nature 183, 612–613 (1959). https://doi.org/10.1038/183612a0
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DOI: https://doi.org/10.1038/183612a0
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