Abstract
RECENTLY, we described a multiple fibroma of the skin in the newt Triturus taeniatus which was characterized by an enlargement of the adepidermal reticular network1–4 and appeared to be transplantable in the same animal3,4. The preliminary transplantation experiments were continued to establish the effect of a colchicine treatment. The material for these experiments was obtained by breeding the normal animals of the first litter in which the tumour was observed3,4. Fragments of tumour tissue from the surroundings of small tumours, in which an enlargement of the nodular swellings of the adepidermal reticular network could already be expected, were transplanted to a perfectly tumour-free area of the same animal, preferably in the tail base region. In 105 of the 128 cases a distinct tumour developed after about 3 weeks at the location of the transplantation, whereas in the 23 negative cases the transplanted material had been almost completely resorbed. After 3 weeks in 83 of the 105 tumour cases treatment with colchicine was applied, the remaining 22 animals being used as controls. This colchicine treatment consisted in giving once a week an intraperitoneal injection of colchicine–saline solution (0.0017 mgm. colchicine). The method of preparing the solution for injection was as usual5–7. The experiment lasted 70 days.
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STOLK, A. Inhibitory Effect of Colchicine upon the Transplantable Fibroma of the Skin in the Newt Triturus taeniatus . Nature 183, 555 (1959). https://doi.org/10.1038/183555a0
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DOI: https://doi.org/10.1038/183555a0
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