Abstract
THE conception that progesterone is the hormone responsible for the maintenance and therefore secondarily also for the onset of labour is based on several important findings: the indispensability of the corpus luteum for pregnancy in the rabbit1; the extraction of the effective substance from corpora lutea2; the role of progesterone in the implantation and early development of the fertilized ovum3; the excretion of progesterone as urinary pregnanediol and the relation between pregnanediol output and the prognosis of pregnancy4; finally, the elucidation of the mechanism of the endocrine control of the pregnant rabbit uterus5–7.
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BENGTSSON, L. Recovery of Injected Progesterone and its Relation to the Onset of Human Labour. Nature 183, 405–406 (1959). https://doi.org/10.1038/183405b0
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DOI: https://doi.org/10.1038/183405b0
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