Presence of Griseofulvin in Hair of Guinea Pigs after Oral Administration

Abstract

GENTLES¹ has found that oral administration of griseofulvin to guinea pigs previously infected with either Microsporum canis or Trichophyton mentagrophytes arrests the progress of the fungal disease and prevents the highly inflammatory reaction normally encountered in untreated animals. Histological examination showed that most of the hair follicles and most of the lower portions of hair-shafts were free from dermatophytes after a few oral doses of the antibiotic. The hyphal tips of the fungi were sometimes malformed and in that way reminiscent of the effect of griseofulvin on other susceptible fungi.