Abstract
COLLOID goitres, resembling those occurring endemically in man, have been produced in the hamster by an iodine-deficient diet followed by repletion with this element after epithelial hyperplasia had developed1. It seemed possible that if proliferative activity of thyroid epithelial cells was produced in this species by other means, such as a goiterogen, colloid accumulation might occur when the stimulus was removed. Such would be in keeping with Marine's hypothesis of the pathogenesis of colloid goitre2. This has proved to be the case. The occurrence of colloid goitre in animals which had received thiouracil and allowed to recover from its effects may be helpful in our understanding of the pathogenesis of endemic goitre in man in cases where absolute iodine deficiency may not be a causative factor.
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References
Follis, jun., R. H., Proc. Soc. Exp. Biol. Med., 100, 203 (1959).
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Follis, jun., R. H., “Deficiency Disease” (Charles C. Thomas, Springfield, 1958).
Mackenzie, C. G., Fed. Proc., 17, Supp. 2, 72 (1958).
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FOLLIS, R. Experimental Colloid Goitre produced by Thiouracil. Nature 183, 1817–1818 (1959). https://doi.org/10.1038/1831817a0
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DOI: https://doi.org/10.1038/1831817a0
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