Abstract
MANY different methods have been applied by several authors to the separation of mono- and di-n-butyl phosphate. Kumler and Eiler1, who were interested in obtaining pure samples for the determination of their dissociation constants, used fractional precipitation of barium salts. Extraction by organic solvents (n-amylic alcohol or dibutylic ether) was applied with a good yield by Stewart and Crandall2; di-n-butyl phosphate is preferentially extracted into the organic phase. With the aim of obtaining mono- and di-n-butyl phosphate labelled with phosphorus-32, after the isotopic transfer of phosphorus-32 from H3 32PO4 to the esters, the exchange resin ‘Dowex 2 X–8’, 100–200 mesh, chloride form, was used by Higgins and Baldwin3 to separate the three components from each other. Thus the mixture at pH 9 was fixed at the top of the resin bed; ortho-phosphoric acid, mono- and di-n-butyl phosphate were consecutively obtained by eluting with 0.05 M hydrochloric acid and with 0.5 M potassium chloride.
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References
Kumler, W. D., and Eiler, J. J., J. Amer. Chem. Soc., 65, 2355 (1943).
Stewart, D. C., and Crandall, H. W., J. Amer. Chem. Soc., 73, 1377 (1951).
Higgins, C. E., and Baldwin, W. H., J. Org. Chem., 21, 1156 (1956).
Wheaton, R. M., and Bauman, W. C., Indust. Eng. Chem., 45, 228 (1953).
Cerrai, E., Cesarano, C., and Gadda, F., Energia Nucleare, 4, 405 (1957).
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CERRAI, E., GADDA, F. Separation of Mono-n-butyl Phosphate and Di-n-butyl Phosphate by means of Ion Exclusion. Nature 183, 1528 (1959). https://doi.org/10.1038/1831528a0
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DOI: https://doi.org/10.1038/1831528a0
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