Abstract
THE rapid development and general acceptance of contrast media represents one of the outstanding successes of diagnostic röntgenology. Roentgen contrast media are generally di- or tri-iodo derivatives of benzene or pyridine, containing further substituents influencing solubility. The most widely used contrast compounds are 3,5-diiodo-4-pyridon-N-acetic acid as its diethanolamine salt (‘Iodopyracet’, ‘Diodrast’, ‘Diodone’, ‘Ioduron’, etc.), and N-methyl-3,5-diiodo-chelidamate as its disodium salt (‘Neo-Iopax’, ‘Iodoxyl’, ‘Uropac’, etc.). A new compound of the urotropic class is sodium-3-acetyl-amino-2,4,6-tri-iodobenzoate known as ‘Triopac’, ‘Urokon’, ‘Triumbren’ and diacetylamino-2,4,6-triiodobenzoic acid, the methylglucamate of which is known as ‘Urografin’. The hepatotropic contrast media are represented by N,N′-adipyl-bis(3-amino-2,4,6-triiodo)-benzoic acid as methylglucamate (‘Biligrafin’ or ‘Cholografin’) and 2-ethyl-3-(3′-amino-2,4,6-triiodophenyl)-propionic acid (‘Cistobil’, ‘Telepaque’).
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LIEBSTER, J., KÁCL, J. & BABICKÝ, A. Labelling of Radiographic Contrast Media with Iodine-131. Nature 183, 1474–1475 (1959). https://doi.org/10.1038/1831474a0
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DOI: https://doi.org/10.1038/1831474a0
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