Abstract
‘TREMORINE’ (1 : 4-dipyrrolidine-butyne) has been proposed1,2 as a test drug against which anti-Parkinsonian agents may be screened and evaluated by their effect on the tremor induced by ‘Tremorine’ in mice. We have investigated the action of the compound in toads, mice, rats and guinea pigs; trials with larger animals, dogs and cats, were restricted by the shortage of ‘Tremorine’.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Everett, G. M., Blockus, L. E., Shepherd, I. M., and Toman, J. E. P., Fed. Proc., 15, 420 (1956).
Blockus, L. E., and Everett, G. M., Fed. Proc., 16, 283 (1957).
Chen, G., J. Pharm. Exp. Therap., 124, 73 (1958).
Kaelber, W. W., and Correll, R. E., A.M.A. Arch. Neurol. Psych., 80, 544 (1958).
Trautner, E. M., and Noack, C. H., Med. J. Austral., 1, 751 (1957). Trautner, E. M., and Gershon, S., Austral. Ann. Med., 70, 286 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TRAUTNER, E., GERSHON, S. Use of ‘Tremorine’ for screening Anti-Parkinsonian Drugs. Nature 183, 1462–1463 (1959). https://doi.org/10.1038/1831462a0
Issue Date:
DOI: https://doi.org/10.1038/1831462a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.