Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours

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DESPITE many investigations of royal jelly1, its chemistry and pharmacological activity have not been completely established. As part of a long-term study on the chemistry and biological activity of royal jelly2 we have recently investigated its possible anti-tumour properties. In this communication we wish to report that admixture of royal jelly with tumour cells before inoculation completely suppresses the development of a transplantable mouse leukæmia and the formation of ascitic tumours in mice. Fractionation studies have established that this anti-tumour activity resides in the main fatty acid of the royal jelly—10-hydroxydecenoic acid.

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  1. 1

    Johansson, S. K., Bee World, 36, 3, 21 (1955).

  2. 2

    Townsend, G. F., and Lucas, C. C., Biochem. J., 34, 1155 (1940).

  3. 3

    Burchenal, J. H., Lester, R. A., Riley, J. B., and Rhoads, C. P., Cancer, 1, 399 (1948).

  4. 4

    Gey, G. O., and Gey, M. K., Amer. J. Cancer, 27, 45 (1936).

  5. 5

    Weisberger, A. S., and Pensky, J., Science, 126, 112 (1957).

  6. 6

    Morgan, J. F., Guerin, L. F., and Morton, H. J., Cancer Res., 16, 907 (1956).

  7. 7

    Hanks, J. H., and Wallace, R. E., Proc. Soc. Exp. Biol. Med., 71, 196 (1949).

  8. 8

    Willson, R. B., Amer. Bee J., 97, 356, 396 (1957).

  9. 9

    Butenandt, A., Nova Acta Leopoldina, N. F., 17, 445 (1955).

  10. 10

    Medes, G., and Weinhouse, S., Cancer Res., 18, 352 (1958).

  11. 11

    Burchenal, J. H., Cremer, M. A., Williams, B. S., and Armstrong, R. A., Cancer Res., 11, 700 (1951).

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TOWNSEND, G., MORGAN, J. & HAZLETT, B. Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours. Nature 183, 1270–1271 (1959) doi:10.1038/1831270a0

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