Abstract
NORMAL guinea pig serum is the most common source of complement for the complement-fixation test, and may be used fresh or, more commonly, preserved either by freeze-drying or by Richardson's method1. Such ‘complement’ is used in the presence of a great variety of antigens, and the possibility of a reaction between components of this serum other than complement and the antigen is usually either ignored or allowed for as an anti-complementary effect of the antigen acting alone.
Similar content being viewed by others
Article PDF
References
Richardson, G. M., Lancet, ii, 696 (1941).
Pillemer, L., and Ecker, E. E., J. Biol. Chem., 137, 139 (1941).
Mayer, M. M., Eaton, B. B., and Heidelberger, M., J. Immunol., 53, 31 (1946).
Pillemer, L., Blum, L., Lepow, I. H., Ross, O. A., Todd, E. W., and Wardlaw, A. C., Science, 120, 279 (1954).
Pillemer, L., Schoenberg, M. D., Blum, L., and Wurz, L., Science, 122, 545 (1955).
McNall, E. G., Proc. Soc. Exp. Biol., N.Y., 94, 399 (1957).
Gronroos, P., Ann. Med. Exp. Fenn. (Helsinki), 33, 310 (1955).
Kagan, I. G., Rice Inst. Pamph., 45, 157 (1958) (quoting Iralu, V., unpublished).
Mackie, T. J., and Watson, H. F., J. Hyg. (Camb.), 25, 176 (1926).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SEWELL, M. Normal Components of Guinea Pig Serum which may cause Antigens to show an Apparent Anti-complementary Effect. Nature 183, 1062 (1959). https://doi.org/10.1038/1831062a0
Issue Date:
DOI: https://doi.org/10.1038/1831062a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.