Letter | Published:

Mast Cells


OBSERVATIONS on the action of cobalt compounds on living organisms revealed that this is to some extent similar to that of histamine. Therefore, as mast cells may produce and/or store histamine and histamine-like substances attached to heparin molecules, it was of interest to see if the cells examined were influenced by cobalt compounds. These were given intraperitoneally to white mice in a single dose of 100 mgm. cobalt/kgm. body-weight, in the form of cobalt nitrate, acetate and chloride. Another series of mice received 5 mgm. cobalt/kgm. in the same salts daily for 3 weeks. Specimens of the skin were fixed and stained by a modified Nowak and Zahl stain1.

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  1. 1

    Nowak, D., and Zahl, W., Stain Technol., 24, 180 (1949).

  2. 2

    Riley, J. F., Science, 118, 332 (1953).

  3. 3

    Fawcett, W., J. Exp. Med., 100, 217 (1954).

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