Abstract
THERE is substantial indirect evidence that acetylcholine increases the conductance of the atrial muscle membrane probably by increasing the permeability to K+ and Cl− 1,2. In addition, acetylcholine has an effect on the sodium-carrying system3. These two actions form the basis of a hypothesis suggested by us3 for the possible explanation of the excitatory and inhibitory actions of acetylcholine on atria described by Burn4.
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References
Trautwein, W., Kuffler, S. W., and Edwards, C., J. Gen. Physiol., 40, 135 (1956).
Harris, E. J., and Hutter, O. F., J. Physiol., 133, 58P (1956).
Johnson, E. A., and Robertson, P. A., Nature, 180, 1483 (1957).
Burn, J. H., “Functions of Autonomic Transmitters” (Williams and Wilkins Co., Baltimore, 1956).
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JOHNSON, E., ROBERTSON, P. Effect of Acetylcholine on the Membrane Resistance and Threshold of Atrial Muscle Fibres. Nature 181, 910–911 (1958). https://doi.org/10.1038/181910a0
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DOI: https://doi.org/10.1038/181910a0
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