Abstract
DURING the systematic study of actinomycetes antagonizing fungi pathogenic in man, a species of Streptomyces (SA-IX/1) was found from desert sand that markedly inhibits growth of Cryptococcus neo-formans and Trichophyton mentagrophytes used for screening1. In laboratory deep fermentation, besides the antifungal antibiotic, an antibacterial one was produced also by this species. A natural stable variant (SA-IX/3) differing morphologically from the original strain isolated was selected that is capable of producing increased quantities of the antifungal and decreased quantities of the antibacterial agent. This proved to be a new species and has been named Streptomyces flavofungini. The antifungal, crystalline antibiotic (Fig. 1) was isolated as a uniform product from the mycelium and fermentation fluid of this asporogenic, chromogenic variant. From its colour and effects, the new antifungal agent has been called ‘flavofungin’.
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Uri, J., Pharmazie, 12, 194 (1957).
Uri, J., Arzneim.-Forsch. (in the press).
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URI, J., BÉKÉSI, I. Flavofungin, a New Crystalline Antifungal Antibiotic: Origin and Biological Properties. Nature 181, 908 (1958). https://doi.org/10.1038/181908a0
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DOI: https://doi.org/10.1038/181908a0
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