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Carcinogenicity of Tricycloquinazoline

Nature volume 181, pages 838–839 (1958)Cite this article

Abstract

TRICYCLOQUINAZOLINE (I) has hitherto been prepared from indazole and copper powder1,2, from o-aminobenzaldehyde and ammonium chloride3 and from o-cyanoanilinium toluene-p-sulphonate2. We now find that it is readily formed in simple pyrolytic reactions. For example, methyl anthranilate was refluxed into a red-hot tube; a benzene solution of the resulting tar, after removal of its constituent acidic and basic fractions including methyl anthranilate, furnished 0.053 per cent of pure trieyclo-quinazoline by chromatography on alumina.

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Authors and Affiliations

  1. The University, Nottingham,

    R. W. BALDWIN, K. BUTLER, F. C. COOPER & M. W. PARTRIDGE

  2. Royal College of Surgeons, London

    G. J. CUNNINGHAM

Authors
  1. R. W. BALDWIN
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  2. K. BUTLER
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  3. F. C. COOPER
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  4. M. W. PARTRIDGE
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  5. G. J. CUNNINGHAM
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BALDWIN, R., BUTLER, K., COOPER, F. et al. Carcinogenicity of Tricycloquinazoline. Nature 181, 838–839 (1958). https://doi.org/10.1038/181838a0

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