Letter | Published:

Avoidance of ‘Secondary Disease’ in Radiation Chimæras


IN the experience of this laboratory the radiation chimæras1, produced by irradiating CBA mice with 950 rads of X-rays and then injecting them intravenously with bone marrow from C 57 BL mice, invariably die within 4 months from ‘secondary disease’. Congdon et al. 2 have worked on the lines that this condition might be due to recovery of the host animals' capacity to eliminate the foreign graft. We3 and Uphoff4 have favoured the idea that it was due to reaction by the graft against the host.

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  1. 1

    Ford, C. E., Hamerton, J. L., Barnes, D. W. H., and Loutit, J. F., Nature, 177, 452 (1956).

  2. 2

    Congdon, C. C., Makinodan, T., and Gengozian, N., J. Nat. Cancer Inst., 18, 603 (1957).

  3. 3

    Barnes, D. W. H., Ford, C. E., Ilbery, P. L. T., Koller, P. C., and Loutit, J. F., J. Comp. Cell Physiol., 50 Supp. 1, 123 (1957).

  4. 4

    Uphoff, D., J. Nat. Cancer Inst., 19, 123 (1957).

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