Perosis and Folic Acid Antagonism in Chickens

Article metrics


THE folic acid antagonist pyrimethamine has been shown to act as a synergist with sulphadimidine against Eimeria tenella in chickens1. During our investigation of this combination, a decreased growth-rate was noted in chickens fed for five days on an all-mash diet containing 100 p.p.m. of pyrimethamine.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Joyner, L. P., and Kendall, S. B., Nature, 176, 975 (1955).

  2. 2

    Daniel, L. J., Farmer, F. A., and Norris, L. C., J. Biol. Chem., 163, 349 (1946).

  3. 3

    Rollo, I. M., Brit. J. Pharmacol., 10, 208 (1955).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ARUNDEL, J. Perosis and Folic Acid Antagonism in Chickens. Nature 181, 342 (1958) doi:10.1038/181342a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.