Abstract
THE folic acid antagonist pyrimethamine has been shown to act as a synergist with sulphadimidine against Eimeria tenella in chickens1. During our investigation of this combination, a decreased growth-rate was noted in chickens fed for five days on an all-mash diet containing 100 p.p.m. of pyrimethamine.
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References
- 1
Joyner, L. P., and Kendall, S. B., Nature, 176, 975 (1955).
- 2
Daniel, L. J., Farmer, F. A., and Norris, L. C., J. Biol. Chem., 163, 349 (1946).
- 3
Rollo, I. M., Brit. J. Pharmacol., 10, 208 (1955).
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ARUNDEL, J. Perosis and Folic Acid Antagonism in Chickens. Nature 181, 342 (1958) doi:10.1038/181342a0
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Further reading
-
Some Effects of Procaine Penicillin on the Pyrimethamine-treated Chick with Special Reference to its Effect on Oviduct Growth Inhibition
Research in Veterinary Science (1965)
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THE EFFICIENCY AND TOXICITY OF PYRIMETHAMINE IN THE CONTROL OF CAECAL COCCIDIOSIS OF CHICKENS
Australian Veterinary Journal (1959)
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