Abstract
ANTISERA prepared by injecting rabbits with cytoplasmic fractions or homogenates of human tissues frequently contain antibodies directed against substances extractable from the tissue with organic solvents and presumably lipid in nature. Material derived from tumours is reported to be more effective than that from normal tissues in eliciting this type of antibody1, suggesting that tumours may contain larger quantities of one or several lipoprotein antigens or possibly antigens qualitatively different. Exploration of this problem by the methods of immunochemical analysis is obstructed by several complications: the antigenic complexity of lipid extracts, the multiplicity of antibodies in the antiserum reagents, and the paucity of information regarding non-specific lipid–protein interactions for many classes of lipids. A fourth complication is of even greater moment than the other three combined, namely, the fact that specific lipid–protein interactions are markedly influenced by certain ubiquitous, non-specific lipids2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Witebsky, E., Klin. Wochenschr., 9, 58 (1930).
Rapport, M. M., Alonzo, N. F., Graf, L., and Skipski, V. P., Cancer (in the press).
Folch, J., Ascoli, I., Lees, M., Meath, J. A., and LeBaron, F. N., J. Biol. Chem., 191, 833 (1951).
Rapport, M. M., and Alonzo, N. F., “Biochemical Problems of Lipids”, edit. by Popjak, G., and LeBetron, E., 69 (Butterworth and Co., Ltd., 1956).
Rapport, M. M., Graf, L., and Alonzo, N. F., Cancer (in the press).
Timell, T. E., Glaudemans, C. P. J., and Currie, A. L., Anal. Chem., 28, 1916 (1956).
Radin, N. S., Brown, J. R., and Lavin, F. B., J. Biol. Chem., 219, 977 (1956).
Isherwood, F. A., and Jermyn, M. A., Biochem. J., 44, 402 (1949).
Rapport, M. M., and Graf, L., Ann. N.Y. Acad. Sci., 69, 608 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RAPPORT, M., GRAF, L., SKIPSKI, V. et al. Cytolipin H, a Pure Lipid Hapten isolated from Human Carcinoma. Nature 181, 1803–1804 (1958). https://doi.org/10.1038/1811803a0
Issue Date:
DOI: https://doi.org/10.1038/1811803a0
This article is cited by
-
Neuropsychiatric manifestations of systemic lupus erythematosus: The value of anticardiolipin, antigangliosides and antigalactocerebrosides antibodies
Clinical Rheumatology (1990)
-
A genetic model for the evolution of the glycosphingolipids
Journal of Molecular Evolution (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.