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Growth of Meningopneumonitis Virus in Normal and Immune Guinea Pig Monocytes

Nature volume 181, pages 1742–1743 (1958)Cite this article

Abstract

RENEWED attention has been focused on the role of cellular resistance to microbial infection, with particular emphasis on both the fate of the organisms and the monocytic phagocytes grown together in vitro 1–5. The use of mononuclear cells constitutes a level of cellular resistance at which fundamental host-parasite relationships can be examined. Accordingly, Mycobacterium tuberculosis 1, Brucella abortus 4, poliovirus5, and vaccinia virus6, among others, proliferate in normal monocytes; however, only a few studies showing suppressed proliferation in immune monocytes have been made in systems in which the monocyte population has been adequately controlled3,4.

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Authors and Affiliations

  1. Department of Bacteriology, University of Kansas, Lawrence, Kansas

    ALBERT A. BENEDICT & CLARENCE MCFARLAND

Authors
  1. ALBERT A. BENEDICT
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  2. CLARENCE MCFARLAND
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BENEDICT, A., MCFARLAND, C. Growth of Meningopneumonitis Virus in Normal and Immune Guinea Pig Monocytes. Nature 181, 1742–1743 (1958). https://doi.org/10.1038/1811742a0

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