Abstract
PREVIOUS studies have shown that subcutaneous injections of trypan blue to rats fed with diets containing N,N,-dimethyl-p-(phenylazo)aniline inhibit the formation of liver tumours1,2. A further attempt to inhibit the experimental production of liver cancer was made with certain compounds related to trypan blue (sodium 3,3′-dimethyldiphenyl-4,4′-bis-azo-(2″)-8″-amino-1″-naphthol-3″,6″-disulphonate). The present communication deals with the effects of direct blue BB and semitrypan blue (see Fig. 1).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Iwase, S., and Fujita, K., Nature, 175, 552 (1954).
Sayama, Y., Miyaji, T., Taki, I., Kawai, K., Uemura, F., Azuma, S., and Hachisuka, T., GANN, 45, 386 (1954).
Simpson, C. Lenore, Brit. J. Exp. Path., 33, 524 (1952).
Fujita, K., Mine, T., Iwase, S., Mizuno, T., Takayanagi, T., Sugiyama, Y., and Aral, T., Brit. J. Exp. Path., 38, 291 (1957).
Richardson, H. L., Stier, A. R., and Borsos-Nachtnebel, E., Cancer Res., 12, 356 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FUJITA, K., MINE, T., ITO, T. et al. Effects of Certain Compounds related to Trypan Blue on the Experimental Production of Liver Cancer. Nature 181, 1732–1733 (1958). https://doi.org/10.1038/1811732a0
Issue Date:
DOI: https://doi.org/10.1038/1811732a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.