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Generation and Propagation of Impulses during Refractoriness in a Pacinian Corpuscle


DEFORMATION of mechano-receptors gives rise to generator potentials which in turn eventually set up propagated potentials. In order to analyse generator potentials it is desirable to block the propagated potential. In the Pacinian corpuscle this may be done by the aid of drugs, by changing the ionic environment of the receptor1 or, as here reported, by taking advantage of differences in duration of the refractory period of generator and propagated events. Generator potentials alone are obtained when the deformation of the receptor occurs during the refractory period of the propagated potential.

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  1. 1

    Gray, J. A. B., and Sato, M., J. Physiol., 129, 594 (1955).

  2. 2

    Loewenstein, W. R., and Altamirano-Orrego, R., Nature, 178, 1292 (1956).

  3. 3

    Gray, J. A. B., and Malcolm, J. L., Proc. Roy. Soc., B, 137, 96 (1950).

  4. 4

    Diamond, J., Gray, J. A. B., and Sato, M., J. Physiol., 133, 54 (1956).

  5. 5

    Alvarez-Buylla, R., and Ramlrez de Arellano, J. R., Amer. J. Physiol., 172, 237 (1953).

  6. 6

    Grundfest, H., Ann. N.Y. Acad. Sci. (in the press).

  7. 7

    Loewenstein, W. R., J. Physiol., 133, 588 (1956).

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