Abstract
THE results of the application of the technique of precipitation in agar gel to a study of the antigenic composition of the virus of foot-and-mouth disease have been reported by Brown and Crick1,2. It was tentatively concluded that two antibodies are present in the serum of guinea pigs and cattle convalescent from the disease on the evidence that (a) two precipitin lines were obtained when suspensions of the virus were diffused towards homotypic serum and (b) formation of one of the precipitin lines could be prevented if the immune serum was mixed with excess of the 7 mµ component of the virus before test. It was considered that the immunoelectrophoretic technique of Grabar and Williams3, in which the protein mixture under examination is first separated in an electric field before analysis by diffusion, might provide further evidence on this point.
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References
Brown, F., and Crick, J., Nature, 179, 316 (1957).
Brown, F., and Crick, J., Virology, 5, 133 (1958).
Grabar, P., and Williams, C. A., Biochim. Biophys. Acta, 10, 193 (1953).
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BROWN, F. Immunoelectrophoretic Evidence for the Presence of Two Precipitating Antibodies in Serum following Infection with the Virus of Foot-and-Mouth Disease. Nature 181, 1130–1131 (1958). https://doi.org/10.1038/1811130a0
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DOI: https://doi.org/10.1038/1811130a0
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