Abstract
IT has been suggested1 that the T2-phage infection first induces the formation of new protein in bacteria before the appearance of phage deoxyribonucleic acid and phage-antigenic protein. Quite recently, however, we have made the important additional discovery that the phage infection also induces a synthesis of new ribonucleic acid, or at least a specific change in its metabolism, and that the formation of this special ribonucleic acid is independent of the prior formation of new protein. These facts suggest that the T2-infection first induces the synthesis of new protein via the formation of new ribonucleic acid or the metabolism of this acid.
Similar content being viewed by others
Article PDF
References
Watanabe, I., Biochim. Biophys. Acta, 25, 665 (1957).
Hershey, A. D., J. Gen. Physiol., 38, 145 (1954).
Volkin, E., and Astrachan, L., Virology, 2, 149 (1956).
Tomizawa, J., and Sunakawa, S., J. Gen. Physiol., 39, 553 (1956).
Burton, K., Biochem. J., 61, 473 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WATANABE, I., KIHO, Y. & MIURA, KI. Effect of Chloramphenicol on Ribonucleic Acid Metabolism in E. coli infected with T2 Phage. Nature 181, 1127 (1958). https://doi.org/10.1038/1811127a0
Issue Date:
DOI: https://doi.org/10.1038/1811127a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.