Letter | Published:

Enzymatic Dehydrogenation of Hydroxypurines and Hydroxypteridines


ONE of the steps of the biosynthesis of guanylic acid from adenylic acid involves the diphosphopyridine nucleotide-linked dehydrogenation of inosinic acid to xanthylic acid1–3: inosinic acid+diphosphopyridine nueleotide+ → xanthylic acid + reduced diphosphopyridine nucleotide. When this reaction was studied with chicken-liver enzyme extracts by following the appearance of the absorption peak at 340 mµ characteristic of reduced diphosphopyridine nucleotide, a strong reduction of the coenzyme was observed not only in the presence of inosinic acid but also with the corresponding purine base hypoxanthine.

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    Lagerkvist, U., Acta Chem. Scand., 9, 1028 (1955).

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    Magasanik, B., Moyed, H. S., and Gehring, L. B., J. Biol. Chem., 226, 339 (1957).

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    Brown, D. J., and Mason, S. F., J. Chem. Soc., 3443 (1956).

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