Letter | Published:

Lipotropic Action of Ethyl Trichloracetate

Naturevolume 180pages859860 (1957) | Download Citation

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Abstract

DURING a study of the biological effects of halogen derivatives of aliphatic acids, the effects of ethyl monochloracetate and ethyl trichloracetate on rat liver have been compared. Ethyl monochloracetate has a toxic effect on liver, whereas equimolecular doses of ethyl trichloracetate cause no apparent change. However, when ethyl trichloracetate is given subcutaneously to choline-deficient rats, the high level of liver lipid is significantly reduced.

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References

  1. 1

    Ridout, J. H., Lucas, C. C., Patterson, J. M., and Best, C. H., Biochem. J., 52, 79 (1952).

  2. 2

    Hartroft, W. S., Anat. Rec., 106, 61 (1950).

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Affiliations

  1. Department of Physiology, University of Queensland, Brisbane

    • C. C. KRATZING
  2. Department of Pathology, Brisbane Hospital, Brisbane

    • G. M. WINDRUM

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https://doi.org/10.1038/180859b0

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