Abstract
DURING a study of the biological effects of halogen derivatives of aliphatic acids, the effects of ethyl monochloracetate and ethyl trichloracetate on rat liver have been compared. Ethyl monochloracetate has a toxic effect on liver, whereas equimolecular doses of ethyl trichloracetate cause no apparent change. However, when ethyl trichloracetate is given subcutaneously to choline-deficient rats, the high level of liver lipid is significantly reduced.
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References
Ridout, J. H., Lucas, C. C., Patterson, J. M., and Best, C. H., Biochem. J., 52, 79 (1952).
Hartroft, W. S., Anat. Rec., 106, 61 (1950).
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KRATZING, C., WINDRUM, G. Lipotropic Action of Ethyl Trichloracetate. Nature 180, 859–860 (1957). https://doi.org/10.1038/180859b0
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DOI: https://doi.org/10.1038/180859b0
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