Abstract
THE International Commission on Radiological Protection in its recommendations1 assumed that radiation damage to the gastrointestinal tract from unabsorbed radioisotopes will be the critical factor in determining the maximum permissible concentration for many of these isotopes. Among the isotopes for which the gastrointestinal tract is considered the critical organ are a number of alpha-emitters. Since it seemed quite conceivable that the radiosensitive cells of the gastrointestinal tract might lie beyond the range of alpha-particles originating within the contents of the tract, experiments were initiated to determine the effect on the tract of an orally administered alpha-emitter.
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References
Recommendations of Int. Comm. Radiol. Protect., Brit. J. Radiol., Supp. No. 6, 46 (1955).
Quastler, H., Radiation Research, 4, 303 (1956). Bond, V. P., Swift, M. N., Allen, A. C., and Fishier, M. C., Amer. J. Physiol., 161, 323 (1956).
Thompson, R. C., and Hollis, O. L., U.S. Atomic Energy Comm., Hanford Atomic Products Operation, Richland, Washington, HW-45546, 27 (1956).
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SULLIVAN, M., THOMPSON, R. Absence of Lethal Radiation Effects following Massive Oral Administration of Plutonium. Nature 180, 651–652 (1957). https://doi.org/10.1038/180651b0
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DOI: https://doi.org/10.1038/180651b0
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