Abstract
THE industrial use of hexanitrodiphenylamine (dipicrylamine, DPA) and the consequent exposure of human beings to it led us to study the chronic toxicity of this compound in experimental animals. In the first part of a feeding test with rats, the substance appeared to have a low toxicity ; but towards the end of the life-span of animals which were fed with large amounts of hexanitrodiphenylamine, we were surprised to see that all the females had big and often multiple mammary tumours. These were fibroadenomata, adenofibromata or fibromata of the same type as occur spontaneously in our rats.
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VAN ESCH, G., VINK, H. & VAN GENDEREN, H. Influence of Hexanitrodiphenylamine on the Incidence of Neoplasms in the Mammary Tissue of Rats. Nature 180, 509–510 (1957). https://doi.org/10.1038/180509a0
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DOI: https://doi.org/10.1038/180509a0
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