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Effect of Copper and Chelating Agents on Growth Inhibition of Aspergillus niger by 8-Hydroxyquinoline and Pyridine-N-Oxide-2-Thiol

Nature volume 180, pages 505–506 (1957)Cite this article

Abstract

WHEN examining the toxicity of chelating agents, we have to deal with the toxicity of each of three entities, namely, the chelating agent itself, the unsaturated complex(es) of metal and chelating agent, and the saturated complex ; for example, for copper and 8-hydroxyquinoline : free oxine, CuOX and CuOX 2. Thus we found1 for Aspergillus niger a minimal growth-inhibitory concentration of 50 p.p.m. for sodium dimethyldithiocarbamate, when the medium was free of heavy metals. The 1 : 2 complex with copper appears to be non-toxic, whereas the 1 : 1 complex is toxic. The activity of the 1 : 1 complex is abolished, however, when copper is removed from this complex by addition of a stronger, non-toxic chelating agent such as sodium dibutyldithiocarbamate.

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Authors and Affiliations

  1. Institute for Organic Chemistry, Utrecht, The Netherlands

    A. KAARS SIJPESTEIJN, M. J. JANSSEN & H. M. DEKHUYZEN

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  1. A. KAARS SIJPESTEIJN
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  2. M. J. JANSSEN
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  3. H. M. DEKHUYZEN
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SIJPESTEIJN, A., JANSSEN, M. & DEKHUYZEN, H. Effect of Copper and Chelating Agents on Growth Inhibition of Aspergillus niger by 8-Hydroxyquinoline and Pyridine-N-Oxide-2-Thiol. Nature 180, 505–506 (1957). https://doi.org/10.1038/180505a0

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