Abstract
THE brain gangliosides of Klenk1 are macro-molecular glycolipids of unknown structure and function, composed of neuraminic acid, sphingosine, fatty acids, hexoses and a hexosamine1–4. Structural evidence has now been obtained by acid hydrolytic cleavage of a highly purified preparation of brain ganglioside. A glucocerebroside has been isolated and the structure of the repeating unit formulated.
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References
Klenk, E., Z. physiol. Chem., 273, 76 (1942).
Bogoch, Samuel, Harvard University Ph.D. thesis, April 1956.
Folch, J., Meath, J. A., and Bogoch, S., Fed. Proc., 15, 254 (1956).
Rosenberg, A., and Chargaff, E., Biochim. Biophys. Acta, 21, 588 (1956).
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BOGOCH, S. Structure of Brain Ganglioside. Nature 180, 197–198 (1957). https://doi.org/10.1038/180197b0
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DOI: https://doi.org/10.1038/180197b0
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