Letter | Published:

Utilization of 4-Amino 5-Imidazole Carboxamide in Plant Tissues

Naturevolume 180page1427 (1957) | Download Citation



THE diazotizable amine which accumulated in cultures of Escherichia coli during sulphonamide bacteriostasis has been isolated and its identity with 4-amino 5-imidazole carboxamide has been established1,2. Evidence to show that this compound was not merely a product of aberrant metabolism but a normal precursor of purines has been obtained3 and its role in purine biosynthesis is well established4. Recently, it was demonstrated that the carboxamide was rapidly utilized in rat liver homogenates and preparations from actively growing tissues5,6. The present report deals with the preliminary experiments carried out to assess the role of this compound as a potential precursor of purines in plants. Resting, as well as germinating, seeds of Phaseolus radiatus (green gram) were used in this investigation.

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  1. 1

    Stetten, M. R., and Fox, jun., C. L., J. Biol. Chem., 161, 333 (1945).

  2. 2

    Shrive, W., Ackermann, W. W., Gordon, M., Getzendaner, M. E., and Eakin, R. E., J. Amer. Chem. Soc., 69, 725 (1947).

  3. 3

    Greenberg, G. R., Fed. Proc., 13, 745 (1954).

  4. 4

    Welch, A. D., in “Enzymes: Units of Biological Structure and Function”, 547 (1956).

  5. 5

    Miller, Z., and Warren, L., J. Biol. Chem., 205, 331 (1953).

  6. 6

    Miller, Z., J. Biol. Chem., 225, 715 (1957).

  7. 7

    Bratton, A. C., and Marshall, jun., E. K., J. Biol. Chem., 128, 537 (1939).

  8. 8

    Giri, K. V., Krishnaswamy, P. R., Kalyankar, G. D., and Narasimha Rao, P. L. N., Experientia, 9, 296 (1953).

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  1. Department of Biochemistry, Indian Institute of Science, Bangalore, 3

    • K. V. GIRI


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