Letter | Published:

A Biochemical Lesion in Congenital, Non-obstructive, Non-hæmolytic Jaundice

Nature volume 180, pages 14261427 (21 December 1957) | Download Citation

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Abstract

CONGENITAL, non-obstructive, non-hæmolytic jaundice is a syndrome characterized by marked elevation of ‘indirect-reacting’ (free) bilirubin in the blood1. Recent studies have shown that bilirubin forms a polar glucuronide which is readily excreted in the bile1. The synthesis of bilirubin glucuronide has been found to be catalysed by an enzyme system in the microsomes of the liver that transfers glucuronic acid from uridine diphosphate glucuronic acid to a Suitable aglycone2. We wish to describe experiments showing that the accumulation of free bilirubin in this syndrome is the result of a defect in the glucuronide-forming mechanism.

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Affiliations

  1. National Institute of Mental Health,

    • JULIUS AXELROD
  2. National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda 14, Md.

    • RUDI SCHMID
    •  & LYDIA HAMMAKER

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https://doi.org/10.1038/1801426a0

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