Abstract
IT is well known that the α-helix configuration of Pauling and Corey1 is associated with a carbonyl stretching mode in the neighbourhood of 1,652–1,655 cm.−1 in films of simple enantiomorphic polypeptides2,3. Since this frequency is also found in the infra-red spectra of films prepared from a number of native proteins4–6 it is of interest to know whether other configurations besides the α-helix are associated with it, for some X-ray diffraction photographs of fibrous proteins suggest a mixture of crystalline and amorphous forms. In the case of water-soluble films of Bombyx mori silk fibroin7, a completely amorphous X-ray diffraction pattern can be obtained, along with a carbonyl band in the infra-red spectrum at 1,660 cm.−1. It is difficult to think that an α-helix arrangement would not produce sufficient order to reveal the characteristic intensity diffraction pattern of this helix.
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References
Pauling, L., and Corey, R. B., Proc. U.S. Nat. Acad. Sci., 37, 235 (1951).
Ambrose, E. J., and Elliott, A., Proc. Roy. Soc., A, 205, 47 (1951).
Elliott, A., Proc. Roy. Soc., A, 221, 104 (1953).
Ambrose, E. J., and Elliott, A., Proc. Roy. Soc., A, 208, 75 (1951).
Rudall, K. M., “Adv. in Protein Chem.”, 7, 253 (1952).
Ambrose, E. J., and Elliott, A., Proc. Roy. Soc., A, 206, 206 (1951).
Ambrose, E. J., Bamford, C. H., Elliott, A., and Hanby, W. E., Nature, 167, 264 (1951).
Yang, J. T., and Doty, P., J. Amer. Chem. Soc., 79, 761 (1957).
Moffitt, W., Proc. U.S. Nat. Acad. Sci., 42, 736 (1956).
Moffitt, W., and Yang, J. T., Proc. U.S. Nat. Acad. Sci., 42, 596 (1956).
Fraser, R. B. D., Disc. Farad. Soc., No. 9, 378 (1950).
Cohen, C., Szent-Györgi, A. G., J. Amer. Chem. Soc., 79, 248 (1957).
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ELLIOTT, A., HANBY, W. & MALCOLM, B. Optical Rotation and Infra-Red Spectra of some Polypeptide and Protein Films. Nature 180, 1340–1341 (1957). https://doi.org/10.1038/1801340b0
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DOI: https://doi.org/10.1038/1801340b0
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