A FEW years ago a study was made in this Department of the role of alcohol in the production of fatty livers and cirrhosis1 in rats. The conclusion was drawn that the hepatotoxic effect of long-continued consumption of non-intoxicating amounts of ethanol was negligible under the experimental conditions. Several repetitions and extensions of the work, which we hope to report elsewhere in the near future, have confirmed the conclusion. In the course of attempts to overcome a technical weakness in the earlier study, namely, some uncertainty as to the exact amount of dilute alcohol consumed daily by the rats, a device was developed by one of us that permits accurate measurements of the liquid drunk by the animals. This so-called ‘Gillespie drinking fountain’, which has now been in use in our rat-colony for about five years, catches any spillage and reduces losses by evaporation to a small known amount (about 300 mgm. or less per day).
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Best, C. H., Hartroft, W. S., Lucas, C. C., and Ridout, J. H., Brit. Med. J., ii, 1001 (1949).
Mardones, J., and Onfray, E., Rev. Chil. Mig. Med. Prev., 4, 293 (1942): 5, 17 (1942).
Mardones, J., Segovia, N., and Onfray, E., Arch. Biochem., 9, 401 (1946).
Mardones, J., Segovia, N., and Hederra, A., Quart. J. Stud. Alc., 14, 1 (1953).
Williams, R. J., Quart. J. Stud. Alc., 7, 567 (1947); J. Clin. Nutr., 1, 32 (1952).
Williams, R. J., Berry, L. J., and Beerstecker, jun., E., Arch. Biochem., 23, 275 (1949).
Rights and permissions
About this article
Cite this article
GILLESPIE, R., LUCAS, C. An Unsuspected Factor which influences Consumption of Alcohol by Rats. Nature 180, 1292–1293 (1957). https://doi.org/10.1038/1801292a0
This article is cited by
The role of orosensory stimuli from ethanol and blood-alcohol levels in producing conditioned taste aversion in the rat
Increased alcohol preference in rats following repeated exposures to alcohol
Zur Frage der Schutzwirkung von Thiamin bei chronischer Alkoholintoxikation
Zeitschrift für Ernährungswissenschaft (1960)
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.