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Coagulant Action of Proteolytic Enzymes

Nature volume 180, pages 1202–1203 (1957)Cite this article

Abstract

Eagle and Harris1 demonstrated that the coagulant actions of papain and trypsin differ. Trypsin acts by converting prothrombin to thrombin: papain clots fibrinogen directly. The thrombin-like action of papain on fibrinogen has been ascribed to its proteolytic property2,3. Light-scattering studies on the papain–fibrinogen reaction4 have shown that the extent of polymerization of fibrinogen is roughly of the same order as in the thrombin–fibrinogen reaction.

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Authors and Affiliations

  1. Dept. of Pathology (Hæmatology), Postgraduate Medical School, University of London, London, W.12.

    HERBERT M. RUBINSTEIN

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  1. HERBERT M. RUBINSTEIN
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RUBINSTEIN, H. Coagulant Action of Proteolytic Enzymes. Nature 180, 1202–1203 (1957). https://doi.org/10.1038/1801202a0

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