Abstract
HAYWARD1 suggested in 1941 that the Nagler reaction might be used for the rapid identification of Clostridium welchii. She expanded this work later2 and directed attention to the difficulty of distinguishing between Cl. welchii and Clostridium bifermentans on serum agar plates. Both these organisms produced opalescence in the medium, and it was inhibited by Cl. welchii antitoxin. She suggested that distinction between these organisms may be made by making use of the hydrolysis of phenolphthalein phosphate as described by Bray and King3.
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References
Hayward, Nancy J., Brit. Med. J., i, 811, 916 (1941).
Hayward, Nancy J., J. Path. Bact., 55, 285 (1943).
Bray, J., and King, E. J., J. Path. Bact., 54, 287 (1942).
Reed, G. B., Dubos's “Bacterial and Mycotic Infections of Man”, 1st ed., 357 (Lippincott, Philadelphia, 1948).
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WILLIS, A., HOBBS, G. A Modified Nagler Medium. Nature 180, 92–93 (1957). https://doi.org/10.1038/180092a0
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DOI: https://doi.org/10.1038/180092a0
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