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Formation of an Enzyme through Complementary Action of Mutant ‘Alleles’ in Separate Nuclei in a Heterocaryon

Abstract

THE am mutants of Neurospora crassa require exogenous α-amino nitrogen for normal growth and lack detectable glutamic acid dehydrogenase1,2. Several such mutants are now known; all are phenotypically similar, and all, on the basis of limited genetic evidence, have hitherto been regarded as due to mutation at the same locus.

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References

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FINCHAM, J., PATEMAN, J. Formation of an Enzyme through Complementary Action of Mutant ‘Alleles’ in Separate Nuclei in a Heterocaryon. Nature 179, 741–742 (1957). https://doi.org/10.1038/179741a0

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