Abstract
THE role of iodine-131 in the possible development of thyroid tumours has been a matter of considerable concern in view of its widespread clinical use. The occurrence of thyroid tumours in rats after single-dose administration of iodine-131 has been described by Goldberg and Chaikoff1; but no reports of such tumour development in other species have been recorded. During the course of an extended investigation of the effects of iodine-131 administered daily to sheep2,3, thyroid adenomas were encountered in four of a group of five sheep which were exposed to 5 µc. iodine-131 per day for their lifetime. The development of a fibrosarcoma in the thyroid region of the remaining member of this group is reported separately4.
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Goldberg, R. C., and Chaikoff, I. L., Arch. Path., 53, 22 (1952).
Bustad, L. K., George, jun., L. A., Marks, S., Warner, D. E., Barnes, C. M., Herde, K. E., and Kornberg, H. A., Radiation Res. (in the press).
Marks, S., Dockum, N. L., and Bustad, L. K., Amer. J. Path. (in the press).
Marks, S., George, jun., L. A., and Bustad, L. K., Cancer (in the press).
Seidell, A., and Fenger, F., J. Biol. Chem., 13, 517 (1913).
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BUSTAD, L., MARKS, S., GEORGE, L. et al. Thyroid Adenomas in Sheep administered Iodine-131 Daily. Nature 179, 677 (1957). https://doi.org/10.1038/179677a0
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DOI: https://doi.org/10.1038/179677a0
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