Inhibition of Acetylcholinesterase by Reserpine in Suspension

Abstract

IN the routine examination of compounds as possible inhibitors of enzymatic reactions, it appears to be fairly common practice to ignore that part of the added compound which remains in suspension in the reaction flask when the limits of solubility have been exceeded. Any inhibition which may be observed is thought to be due to the portion in solution. The necessity to remove the insoluble material from the system has been made clear in the course of a study to determine if reserpine would act as an inhibitor of acetylcholinesterase.

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References

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    Ammon, R., Pflügers Arch., 233, 486 (1933).

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    Vincent, D., and Sero, I., C.R. Soc. Biol., 136, 612 (1942).

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SHEPPARD, H., TSIEN, W. & PLUMMER, A. Inhibition of Acetylcholinesterase by Reserpine in Suspension. Nature 179, 587–588 (1957). https://doi.org/10.1038/179587a0

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