The Antihæmophilic and Christmas Factor Activities of Ethanol Fractions of Brain Extract

Abstract

THE activity of brain tissue extract in the mechanism of blood coagulation is considered to be equivalent to a combination of platelets, antihæmophilic globulin and Christmas factor1 (plasma thromboplastin component). The latter two blood-clotting factors have been separated in different ethanol fractions of plasma. It was thus of interest, following our report on the isolation of antihæmophilic globulin from brain tissue2, to study the antihæmophilic and Christmas factor activities of various ethanol fractions obtained from brain extract.

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References

  1. 1

    Biggs, R., Douglas, A. S., and Macfarlane, R. G., J. Physiol., 122, 554 (1953).

  2. 2

    Nour-Eldin, F., and Wilkinson, J. F., Brit. J. Hæmat., 2, 433 (1956).

  3. 3

    Cohn, E. J., Strong, L. E., Hughes, jun., W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 459 (1946).

  4. 4

    Cohn, E. J., Gurd, F. R. N., Surgenor, D. M., Barnes, B. A., Brown R. K., Derouaux, G., Gillespie, J. M., Kahnt, F. W., Lever, W. F., Liu, C. H., Mittleman, R. F., Mouton, K., Schmid, K., and Uroma, E., J. Amer. Chem. Soc., 72, 465 (1950).

  5. 5

    Oncley, J. L., Melin, M., Richert, D. A., Cameron, J. W., and Gross, jun., P. M., J. Amer. Chem. Soc., 71, 541 (1949).

  6. 6

    White, S. G., Aggeler, P. M., and Emery, B. E., Proc. Soc. Exp. Biol., N.Y., 83, 69 (1953).

  7. 7

    Spaet, T. H., and Kinsell, B. G., Proc. Soc. Exp. Biol., N.Y., 84, 314 (1953).

  8. 8

    Aggeler, P. M., Spaet, T. H., and Emery, B. E., Science, 119, 806 (1954).

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NOUR-ELDIN, F., WILKINSON, J. The Antihæmophilic and Christmas Factor Activities of Ethanol Fractions of Brain Extract. Nature 179, 532–533 (1957). https://doi.org/10.1038/179532b0

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