Abstract
SOME aspects of the chemical and biological activity of the inorganic complex ions have been previously reported by Beccari1 and by Dwyer and co-workers2–4. These workers have indicated that the complex cations show extremely high chemical stability, and most probably pass through the body unchanged. They also exhibit marked biological activity4, and when injected intraperitoneally into mice2 cause paralysis and death by respiratory failure suggestive of curariform activity. We have investigated their pharmacological mode of action on the rat diaphragm–phrenic nerve and toad (Bufo marinus) rectus abdominis muscle preparations. Investigations have also been carried out, in collaboration with Dr. Rosamond M. Eccles, of the Department of Physiology, Australian National University, using the toad sartorius nerve–muscle preparation and the isolated superior cervical ganglion of the rabbit.
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References
Beccari, E., Boll. soc. ital. biol. sper., 13, 6 and 8 (1938) 16, 214 and 216 (1941); Arch. sci. biol. (Italy), 27, 204 (1941); Arch. sci. Physiol., 3, 611 (1949).
Dwyer, F. P., Gyarfas, E. C., Koch, J., and Rogers, W. P., Nature, 170, 190 (1952).
Dwver, F. P., Gyarfas, E. C., Koch, J., Rogers, W. P., and Simmonds, R. (unpublished work).
Brandt, W. W., Dwyer, F. P., and Gyarfas, E. C., Chem. Rev., 54/6, 959 (1954).
Eccles, R. M., J. Physiol., 117, 181 and 196 (1952).
Ing, H. R., Physiol. Rev., 16, 527 (1936). Holmes, P. E. B., Jenden, D. J., and Taylor, D. B., Nature, 159, 86 (1947). Taylor, D. B., Pharmacol. Rev., 3, 412 (1951). Riker, W. F., Roberts, J., Reilly, J., and Roy, B. B., Fed. Proc., 13, 398 (1954).
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DWYER, F., GYARFAS, E., WRIGHT, R. et al. Effect of Inorganic Complex Ions on Transmission at a Neuromuscular Junction. Nature 179, 425–426 (1957). https://doi.org/10.1038/179425a0
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DOI: https://doi.org/10.1038/179425a0
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