Abstract
LAST year, Hoagland1 reported that he had obtained from rat liver a soluble enzyme preparation which catalysed the formation of amino-acid hydroxamates when incubated with a mixture of twelve amino-acids in the presence of adenosine triphosphate and hydroxylamine. He suggested that this type of carboxyl group activation might be a first step in protein synthesis. In a later paper with Keller and Zamecnik2 he reported partial purification of activating enzyme from liver.
Similar content being viewed by others
Article PDF
References
Hoagland, M. B., Biochim. Biophys. Acta, 16, 288 (1955).
Hoagland, M. B., Keller, E. B., and Zamecnik, P. C., J. Biol. Chem., 218, 345 (1956).
Keller, E. B., and Zamecnik, P. C., J. Biol. Chem., 221, 45 (1956).
Demoss, J. A., and Novelli, G. D., Biochim. Biophys. Acta, 22, 49 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COLE, R., COOTE, J. & WORK, T. Activation of Amino-acids by Soluble Enzymes from Pancreas and Other Tissues. Nature 179, 199 (1957). https://doi.org/10.1038/179199a0
Issue Date:
DOI: https://doi.org/10.1038/179199a0
This article is cited by
-
Notes on the hydroxamate assay for amino acid activating enzymes
Experientia (1960)
-
Biochemical Approaches to the Problem of Protein Synthesis
Nature (1957)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.