Abstract
POLYMORPHISM in aprobarbital (5 allyl 5-isopropyl barbituric acid) has been reported by several workers1–3. Three modifications are quite stable and have been well described in the literature, and a fourth modification has been prepared by Brandstätter2, who has reported only a melting point, and gives no preparative details. Hnang5 has attempted to prepare this modification IV, but although a new crystal habit was observed, it was found to have the same X-ray diffraction pattern as modification III.
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References
Fischer, R., Arch. Pharm. u. Ber. dtsch. pharm. Gesel., 270, 149 (1932); Mikrochemie, 10, 409 (1932). Reimers, F., Dansk. Tids. Farm., 14, 1 (1940).
Brandstätter, Maria, Z. physik. Chem., A, 191, 227 (1942).
Huang, T-Y., Acta Pharm. Intern., 2, 95 (1951).
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WILLIAMS, P. An Unstable Modification of Aprobarbital. Nature 179, 1189 (1957). https://doi.org/10.1038/1791189a0
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DOI: https://doi.org/10.1038/1791189a0
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