Abstract
EFFORTS aimed at establishing a biochemical mechanism for carcinogenic action have included studies of the inhibition of unsaturated lipid oxidation by carcinogenic compounds1. The hæmatin compounds, particularly hæmoglobin, myoglobin and cytochrome c, appear to be the main catalysts of unsaturated lipid oxidation occurring in animal tissues. This reaction has been postulated to be of prime importance in many types of pathological unsaturated fat oxidation in vivo2. This report presents results of studies undertaken in an attempt to demonstrate what, if any, effects were induced by the presence of certain carcinogenic compounds in in vitro hæmatin-catalysed unsaturated fat oxidation systems.
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References
Bernheim, M. L. C., Bernheim, F., and Wilbur, K. M., Nature, 172, 306 (1953).
Tappel, A. L., Arch. Biochem. and Biophys., 50, 473 (1954); 54, 266 (1955). Hove, E. L., Amer. J. Clin. Nutr., 3, 328 (1955).
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BROWN, W., TAPPEL, A. Effect of Carcinogenic Compounds on the Hæmatin-catalysed Oxidation of Unsaturated Fat. Nature 179, 105–106 (1957). https://doi.org/10.1038/179105a0
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DOI: https://doi.org/10.1038/179105a0
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